Guar Food Derivative FOR PHARMACEUTICALS Industr
30 years ago, guar gum was mainly used as a disintegrate and binder in tablet. Today, guar gum is also used as a controlled-release agent for drug. Guar gum, drug and other ingredients are mixed and compressed into tablets. During dissolution studies, guar gum hydrates and forms a thick gel layer on the tablet surface. Consequently, drug releases out from the guar gum tablet in a sustained manner, achieving the desired kinetic effect. It also has been observed that bacterial flora in the large intestine degrade guar gum rapidly. Consequently, scientists developed successful delivery systems using guar gum to target drugs to ileum and large intestine.
Some people use guar gum to decrease appetite by providing a “feeling of fullness.” However, because of its swelling properties, guar gum may cause obstruction of the esophagus. Guar gum can swell as much as 20 fold. As discussed before, guar gum may retard chemical absorption. The chemicals also include glucose. Consequently, it may cause significant fluctuations in blood sugar levels. People with diabetes should not use these preparations. After fermentation of guar gum in the large intestine, the products including carbon dioxide, fatty acid and hydrogen will lower the pH of the medium. Researchers observed that ingestion of guar gum decreased the cholesterol and triglyceride levels but guar gum or other water-soluble, fermentable fibers increased the odd for colorectal cancer in a study of rats. One group explained that the soluble fiber did not raise distal butyrate concentration high enough to protect the colon from cancer. Butyrate demonstrated to slow the growth of cancer cells cultured in vitro. While, one group found that dietary fiber supplementation with 10% pectin or with 10% guar gum (fed during the promotional stage of carcinogen sis) suppressed colon cancer incidence to a significant extent in study of rats. Other found that guar gum was not carcinogenic. The inconsistent research findings on guar gum’s carcinogenic effect demonstrate the importance of experimental design.
|Appearance||Fine Off white (Creamish)|
|Odour||Odorless to very bland|
|Solubility||Easy soluble in Cold Water|
|Particle size||200 mesh and 300 mesh|
|Texture||Free flowing powder|
|Viscosity of 1% paste||4000 cps – 5000 cps|
Typical Chemical Properties
|Moisture||12 % max|
|Ash content||1.2 % max|
| Acid insoluble Matter
| 2.5% max
10 PPM Max.
| Carbohydrate including Gum contents
| 85% minimum
03 PPM Max.
|Non Pathogenic Bacteria||10,000 gm. Max.|
The recommended Level of Gaur Gum Pharmaceuticals Product 0.50 % to 1.00 % Mean 05 Gm / 1000Gm To 10Gm / 1000Gm.
This is special suggestion for your Pharmaceuticals industry For best result according your need .
1.00 % mean 1Gm for 100 kg Of Compound .
25 Kg. laminated paper bags with PE lining inside.
Sealed bag under normal condition for 6 months.
Guar Gum should be stored in cool and dry place, away from direct sun light.